Tag Archives: Kidney

Massive lymphocele associated with renal allograft hydronephrosis

Approximately 3 weeks after deceased donor kidney transplantation, a patient developed oliguric renal failure. Renal sonogram demonstrated moderate hydronephrosis of the renal allograft secondary to compression of the transplanted ureter by a large fluid collection in the pelvis (Figure 1, top panel). CT scan confirmed the same (Figure 2) and the patient underwent ultrasound-guided drainage of ~450 cc fluid the next day with drain placement leading to improvement in urine output. Laboratory analysis of the fluid was consistent with lymphocele and repeat sonogram showed significant improvement (Figure 1, bottom panel).

Lymphocele is a lymphocyte-rich fluid collection that results from disruption of lymphatics in the recipient during renal transplantation. While small collections resolve spontaneously, larger, symptomatic ones may cause obstructive nephropathy requiring percutaneous or laparoscopic drainage. Prompt diagnosis obviates the need for renal replacement therapy.

A case of bilateral hydronephrosis

A young woman presented with abdominal pain that did not get better with empiric antibiotic therapy for presumed urinary tract infection. Renal sonogram revealed bilateral mild to moderate hydronephrosis. There were no stones, but scan of the bladder area revealed a protruding mass with pressure effect on the urinary bladder, which was the likely cause for hydronephrosis. Biopsy of the mass revealed B-cell lymphoma. She was started on chemotherapy and required placement of bilateral nephrostomy tubes for urinary obstruction.

Take home points:

Do not forget to scan the bladder when you see hydronephrosis

In women, always consider pelvic malignancy in addition to urolithiasis when unilateral or bilateral hydronephrosis is detected

Retroperitoneal lymphoma

Here is a renal sonogram obtained from an elderly woman demonstrating bilateral hydronephrosis as well as a heterogeneous mass encasing the left kidney.

CT scan of the abdomen included for comparison: shows multilobulated retroperitoneal soft tissue mass (arrow) encasing the left kidney (LK) causing its displacement anteriorly and superiorly. Similar mass involving the right kidney (RK) can be noted, but to a lesser extent (arrow).

Unfortunately, biopsy of the mass revealed aggressive B cell lymphoma.

Learning point: Lymphoma can present as obstructive nephropathy; pay attention to the area surrounding the kidney. In fact, the diagnosis was missed on a prior point of care ultrasound in this patient.

Maternal Physiologic hydronephrosis in Pregnancy

Pregnancy-related hydronephrosis, more precisely physiologic maternal renal pelvis dilatation is common and the incidence is estimated to be as high as 80%. The dilatation of the pelvis and ureter typically develops toward the end of second trimester and disappears within a few weeks after delivery. It is more common in primigravid women and usually more prominent on the right side. Etiology includes extrinsic ureteral compression by the gravid uterus on top of reduced ureteral smooth muscle tone and peristalsis due to progesterone effect.

Right sided predominance may be due to dextrorotation of the uterus by the sigmoid colon, kinking of the ureter as it crosses the right iliac artery, and/or proximity to the right ovarian vein. Following figure gives an idea of the anatomy.

In these cases, it is often difficult to trace the ureter to the point of obstruction. However, in pathologic hydronephrosis, one may visualize the source of obstruction (e.g. stone). In addition, if the pelvic diameter exceeds 10 mm, pathologic dilatation should be suspected.

Here is a case of mild bilateral hydronephrosis in a primigravid pregnant woman during third trimester. Note weak left ureteral jet compared to normal. Color Doppler could not pick up the right jet despite maintaining the probe position for approximately 2 minutes consistent with obstruction.

Renal abscess

A middle-aged man with diabetes mellitus type 2 presented with fever, chills and malaise. Urinalysis revealed pyuria and was positive for nitrite. Renal sonogram demonstrated a heterogeneous mass-like structure in the mid right kidney extending over the lower pole.

CT scan and MRI with contrast were suggestive of renal abscess. A drainage catheter was placed and patient started on intravenous antibiotics. Fluid culture grew Klebsiella pneumoniae and the therapy was tailored accordingly. 1-week later, a repeat sonogram demonstrated near-complete resolution of the collection.

On a sonogram, renal abscess appears as a well-defined hypoechoic area often with thick walls and internal echoes. Can be associated with surrounding diffusely hypoechoic, enlarged kidney due to pyelonephritis or hydronephrosis interspersed with echogenicities if it ruptures into the collecting system = pyonephrosis. It may appear similar to an organizing hematoma or renal cell carcinoma as in the above case where history becomes crucial and further imaging should be obtained. Small abscesses can be totally missed on ultrasound. Following are two more examples.

For renal abscesses <5 cm in diameter, antibiotic therapy alone without drainage is appropriate initial management. These lesions usually respond well to prolonged antibiotic treatment, and moreover, radiographic localization for drainage can be difficult. If clinical symptoms and radiographic findings persist after several days of antimicrobial therapy, drainage should be considered.

Renal abscesses >5 cm should be managed with percutaneous drainage in addition to antimicrobial therapy.

Renal angiomyolipoma

A classic angiomyolipoma (AML) has abundant fat and therefore appears hyperechoic on a sonogram, similar to the sinus fat. Acoustic shadowing may be seen in up to a 3rd of the lesions. Unlike stones, these lesions do not typically exhibit twinkle artefact on color Doppler. Definitive diagnosis of AML is possible only by CT or MRI because they ‘diagnose’ fat and ultrasound can only ‘suggest’ fat. On non-contrast CT scan, the presence of regions of interest containing attenuations less than -10 HU allows confident identification of fat. Following are some examples of classic AMLs.

In patients with tuberous sclerosis, multiple renal AMLs are seen and often difficult to characterize on ultrasound. Corticomedullary differentiation is typically lost. Management should be guided by CT or MRI in such cases. Following is an example.

Small, well circumscribed bright lesions can be followed by ultrasound alone while any suspicion for malignancy warrants CT or MRI. The following lesion looks hyperechoic and most likely is AML but I would get a CT if possible because it’s more hypoechoic compared to sinus fat.

Renal cell carcinomas are hypoechoic to heterogeneous. They can be isoechoic also, which can be easily missed on quick scans. Therefore, it is important to image kidneys from multiple scan planes. Hardly takes an additional minute of your time! In addition, if you see anechoic rim surrounding the lesion or intralesional cysts or calcifications, think renal cell carcinoma. Following are some examples of RCC.

“Fat-poor AMLs” can be of heterogeneous echotexture or just isoechoic to renal parenchyma. It is challenging to differentiate them from malignancy and therefore, almost always require further imaging.

Renal milk of calcium cysts

Renal milk of calcium refers to the viscous colloidal suspension of calcium salts found either within a calyceal diverticulum or within a simple renal cyst. Unlike stones, milk of calcium is typically asymptomatic and does not require intervention. In fact, shock wave lithotripsy is ineffective for the treatment.

The etiology of milk of calcium is unclear; however, it may be related to urine stagnation (obstruction) and infection. As a colloid suspension, the calcium salts gravitate to the most dependent portion of the cavity. This layering (gravitational) effect leads to the radiological finding of crescent-shaped dense lesion with a fluid level at the upper border of the stone and may change positions with patients’ position. This finding is reported in KUB, ultrasound and more evident on CT scan. Acoustic shadowing is usually absent but may be seen with larger depositions. Reverberation artefact is seen sometimes.

This entity can be seen in the gall bladder also, and may be associated with chronic cholecystitis. However, ultrasound is non-specific for differentiating gall bladder sludge from milk of calcium, and CT or plain radiographs usually suggest the diagnosis.